Location History:
- Westfield, NJ (US) (1998 - 2001)
- Montclair, NJ (US) (2002)
Company Filing History:
Years Active: 1998-2002
Title: Joseph A Borkowski: Innovator in Biochemistry
Introduction
Joseph A Borkowski is a notable inventor based in Westfield, NJ (US). He has made significant contributions to the field of biochemistry, particularly in the area of receptor biology. With a total of 5 patents to his name, Borkowski's work has had a substantial impact on pharmaceutical research.
Latest Patents
One of his latest patents is focused on the cloned and expressed human bradykinin BK-2 receptor. This invention involves a cloned human BK-2 bradykinin receptor derived from a human lung fibroblast cell line. The cDNA clone encodes a novel 364 amino acid protein that exhibits the characteristics of a seven transmembrane domain G-protein coupled receptor. This invention is utilized to express the BK-2 bradykinin receptor in host mammalian cells, enabling the screening for pharmaceutical antagonists or agonists that interact with the BK-2 bradykinin receptor protein. Another significant patent involves bradykinin B1 receptor antibodies. In this work, DNAs encoding bradykinin B1 receptors from mammalian cells have been cloned and characterized. The recombinant receptor can form receptors that bind desArg-kallidin and other B1-specific ligands. The DNA has been expressed in recombinant host cells, which produce active recombinant protein, facilitating the identification of modulators of receptor activity.
Career Highlights
Joseph A Borkowski is currently associated with Merck & Company, Inc., where he continues to advance his research in biochemistry. His work has been instrumental in developing methods that enhance the understanding of receptor functions and their implications in drug development.
Collaborations
Throughout his career, Borkowski has collaborated with esteemed colleagues, including John W Hess and David L Linemeyer. These collaborations have further enriched his research and contributed to the advancement of biochemistry.
Conclusion
Joseph A Borkowski's innovative work in the field of biochemistry, particularly in receptor biology, has led to significant advancements in pharmaceutical research. His contributions continue to influence the development of new therapeutic strategies.