Location History:
- Riehen, CH (1994 - 1997)
- Schutzengasse, CH (1998)
Company Filing History:
2 out of 6,850 
1 out of 166 
1 out of 2 Years Active: 1994-1998
Title: The Innovations of Josef Bruggen
Introduction
Josef Bruggen is a notable inventor based in Riehen, Switzerland. He has made significant contributions to the field of biotechnology, particularly in the area of inflammatory conditions and related diseases. With a total of 4 patents to his name, Bruggen's work has had a profound impact on medical research and therapeutic methods.
Latest Patents
Bruggen's latest patents include groundbreaking inventions that address critical health issues. One of his notable inventions is a cytokine that mediates inflammation. This invention concerns polypeptides with an apparent molecular weight of around 160 kD, which serve as mediators or precursors for mediators of inflammation. The patent also covers derivatives such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for the polypeptides and derivatives, and host cells transformed with such hybrid vectors. Additionally, it includes polyclonal and monoclonal antibodies specific for the polypeptides or their derivatives, along with diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.
Another significant patent involves DNAs encoding human macrophage migration inhibition factor related polypeptides, specifically MRP-8 and MRP-14. This invention outlines processes for their preparation, mRNAs, DNAs, and hybrid vectors coding for those polypeptides. It also includes hosts transformed with such a hybrid vector, monoclonal and polyclonal antibodies to those polypeptides, and diagnostic methods for inflammatory conditions and cystic fibrosis.
Career Highlights
Throughout his career, Bruggen has worked with prominent companies in the pharmaceutical industry, including Ciba-Geigy Corporation and Novartis Corporation. His experience in these organizations has allowed him to develop and refine his innovative ideas, contributing to advancements in medical science.
Collaborations
Bruggen has collaborated with esteemed colleagues such as Karel Gerrit Odink and Nico Cerletti. These partnerships have fostered a collaborative environment that has led to significant advancements in their respective fields.
Conclusion
Josef Bruggen's contributions to biotechnology and his innovative patents have made a lasting impact on the medical community. His work continues to inspire future research and development in the treatment of inflammatory conditions and related diseases.