This inventor holds 1 USPTO granted patent and 1 published patent application. Top assignee: Rosalind Franklin University of Medicine and Science. Active years: 2018.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 2018
Title: Innovations in Parkinson's Disease Diagnosis by Jose Alfredo Santiago
Introduction
Jose Alfredo Santiago is an accomplished inventor based in North Chicago, IL (US). He has made significant contributions to the field of medical diagnostics, particularly in relation to Parkinson's disease. His innovative work focuses on identifying biomarkers that can aid in the diagnosis and monitoring of this complex condition.
Latest Patents
Jose Alfredo Santiago holds a patent for "Methods and kits for diagnosing, prognosing and monitoring Parkinson's disease." This patent highlights a network-based meta-analysis of four independent microarray studies that identified the hepatocyte nuclear factor (HNF4A) as a central regulatory hub gene upregulated in the blood of Parkinson's disease patients. In contrast, the polypyrimidine tract binding protein 1 (PTBP1) was identified as the most downregulated gene. Using these two markers, Parkinson's disease patients were classified with 90% sensitivity and 80% specificity. Longitudinal performance analysis demonstrated that the relative abundance of HNF4A and PTBP1 mRNAs significantly decreased and increased, respectively, in Parkinson's disease patients during a three-year follow-up period. The inverse regulation of HNF4A and PTBP1 provides a molecular rationale for the altered insulin signaling observed in these patients. The dynamic biomarkers identified in this study may be useful for monitoring disease-modifying therapies for Parkinson's disease.
Career Highlights
Jose Alfredo Santiago is affiliated with Rosalind Franklin University of Medicine and Science, where he continues to advance research in the field of neurology. His work has garnered attention for its potential to improve the lives of those affected by Parkinson's disease.
Collaborations
One of his notable collaborators is Judith Ann Potashkin, with whom he has worked on various research initiatives aimed at understanding and treating Parkinson's disease.
Conclusion
Jose Alfredo Santiago's innovative contributions to the diagnosis and monitoring of Parkinson's disease exemplify the importance of research in improving patient outcomes. His work not only enhances our understanding of the disease but also paves the way for future advancements in medical diagnostics.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile