Jordan J N Tang

Title: Innovations of Jordan J N Tang in Memapsin Research

Introduction

Jordan J N Tang is a prominent inventor based in Edmond, OK (US), known for his significant contributions to the field of biochemistry and enzymology. He holds a total of 9 patents, focusing primarily on the development of inhibitors for memapsin 2, which have implications for Alzheimer's disease treatment.

Latest Patents

His latest patents include groundbreaking work on "Catalytically active recombinant memapsin and methods of use thereof" and "Inhibitors of Memapsin 2 and use thereof." These patents detail methods for producing purified, catalytically active recombinant memapsin 2 and the design of substrate analogs that inhibit its function. The substrate analogs are based on peptide sequences related to natural substrates for memapsin 2. Notably, the analog OM99-2 has shown an inhibition constant of 1.6×10M against recombinant pro-memapsin 2. The crystallography studies conducted on memapsin 2 bound to this inhibitor have provided insights into the three-dimensional structure of the protein, which can aid in the design of new inhibitors for diagnostic and therapeutic purposes.

Career Highlights

Throughout his career, Jordan has worked with esteemed institutions such as the Oklahoma Medical Research Foundation and the University of Illinois. His research has significantly advanced the understanding of memapsin 2 and its role in Alzheimer's disease.

Collaborations

Jordan has collaborated with notable colleagues, including Arun K Ghosh and Xinli Lin, contributing to the collective knowledge in the field of enzymology and drug design.

Conclusion

Jordan J N Tang's innovative work in the development of memapsin 2 inhibitors showcases his dedication to advancing medical science and offers hope for future Alzheimer's disease treatments. His contributions are invaluable to the ongoing research in this critical area.