Company Filing History:
Years Active: 2013-2016
Title: Jooho Shin: Innovator in Parkinson's Disease Research
Introduction
Jooho Shin is a prominent inventor based in Ellicott City, MD (US), known for his significant contributions to the field of neurodegenerative diseases, particularly Parkinson's disease. With a total of 3 patents to his name, Shin's work focuses on understanding the molecular mechanisms underlying this debilitating condition.
Latest Patents
One of Jooho Shin's latest patents addresses the transcriptional repression leading to Parkinson's disease. This research identifies a Parkin Interacting Substrate, PARIS (ZNF746), which plays a crucial role in the preferential loss of substantia nigra dopamine neurons. The levels of PARIS are regulated by the ubiquitin proteasome system through binding to and ubiquitination by the E3 ubiquitin ligase, parkin. PARIS is characterized as a KRAB and zinc finger protein that accumulates in models of parkin inactivation and in the brains of human Parkinson's disease patients. It represses the expression of the transcriptional co-activator, PGC-1α, and the PGC-1α target gene, NRF-1, by binding to insulin response sequences in the PGC-1α promoter. Conditional knockout of parkin in adult animals leads to a progressive loss of dopamine (DA) neurons that is dependent on PARIS. Furthermore, overexpression of PARIS results in selective loss of DA neurons in the substantia nigra, which can be reversed by either parkin or PGC-1α co-expression. The identification of PARIS provides a molecular mechanism for neurodegeneration due to parkin inactivation.
Career Highlights
Jooho Shin is currently associated with Valted, LLC, where he continues to advance his research in neurodegenerative diseases. His innovative work has garnered attention in the scientific community, contributing to a deeper understanding of Parkinson's disease.
Collaborations
Shin has collaborated with notable researchers, including Ted M. Dawson and Valina L. Dawson, enhancing the impact of his work through shared expertise and insights.
Conclusion
Jooho Shin's contributions to the understanding of Parkinson's disease through his innovative research and patents highlight his role as a key figure in the field of neurodegenerative disease research. His work continues to pave the way for potential