Jongho Jeon

Title: Jongho Jeon: Innovator in Nano-Aggregation Probes

Introduction

Jongho Jeon is a prominent inventor based in Palo Alto, CA. He has made significant contributions to the field of biomedical engineering, particularly in the development of innovative probes for imaging and therapeutic applications. His work focuses on enhancing the detection and treatment of apoptotic tumor cells.

Latest Patents

Jongho Jeon holds a patent for "Caspase-triggered nano-aggregation probes and methods of use." This patent describes an activatable probe that undergoes intramolecular cyclization and subsequent aggregation in apoptotic tumor cells upon peptidase-initiated activation, specifically targeting caspase-3. The caspase-sensitive nano-aggregation probes (C-SNAFs) are designed to be biocompatible and possess near-infrared (NIR) spectral properties. They may also serve as imaging agents for PET or MRI. The mechanism of these probes allows for target-mediated nanostructure self-assembly, making them suitable for in vivo applications. The probes utilize biocompatible condensation chemistry products that include D-cysteine and 2-cyano-6-hydroxyquinoline (CHQ) moieties linked to an amino-luciferin scaffold. Activation occurs through a two-step reaction involving caspase-3/7-mediated cleavage of an L-DEVD capping peptide and the reduction of a disulfide bond by free intracellular thiols. He has 1 patent to his name.

Career Highlights

Jongho Jeon is affiliated with Leland Stanford Junior University, where he continues to advance his research in the field of nano-aggregation probes. His innovative work has the potential to significantly impact cancer diagnostics and treatment.

Collaborations

Jongho collaborates with notable colleagues, including Deju Ye and Adam Shuhendler, who contribute to his research endeavors and help drive forward the development of new technologies in the biomedical field.

Conclusion

Jongho Jeon is a key figure in the innovation of caspase-triggered nano-aggregation probes, which hold promise for improving cancer imaging and treatment. His contributions to the field are noteworthy and continue to inspire advancements in biomedical engineering.