Jones Tim

Title: Innovations of Tim Jones in Protein Engineering

Introduction

Tim Jones is a notable inventor based in Babraham, GB, recognized for his contributions to the field of protein engineering. He holds 2 patents that focus on the development of artificial proteins with reduced immunogenicity. His work aims to enhance the efficacy of biologically active molecules while minimizing immune reactions in living organisms.

Latest Patents

Jones's latest patents include innovations in artificial modified proteins, particularly fusion proteins. One of his significant inventions involves creating immunoglobulin fusion proteins that consist of an immunoglobulin molecule or a fragment covalently fused to a biologically active non-immunoglobulin molecule. This invention is designed to reduce immunogenicity compared to the parent non-modified molecule when exposed to a species in vivo. The fusion proteins are engineered to maintain the same biological activity as their non-altered counterparts while altering specific amino acid sequences in regions identified as T-cell epitopes. This innovative approach also includes a novel method for producing such fusion proteins through computer-aided identification of T-cell epitope values for MHC Class II molecule binding sites.

Another patent focuses on anti-KSA/IL-2 fusion proteins with similar objectives of reducing immunogenicity. This invention also emphasizes the importance of maintaining biological activity while modifying amino acid sequences to minimize immune responses. The methodologies developed by Jones represent significant advancements in the field of immunology and protein engineering.

Career Highlights

Tim Jones has made substantial contributions to the scientific community through his innovative research and patent filings. His work at Merck Patent GmbH has positioned him as a key figure in the development of advanced therapeutic proteins. His expertise in protein engineering has led to breakthroughs that could potentially transform treatment options in various medical fields.

Collaborations

Jones collaborates with esteemed colleagues such as Stephen D Gillies and Francis Joseph Carr. Their combined expertise fosters an environment of innovation and progress in the realm of protein research.

Conclusion

Tim Jones's work in the field of protein engineering exemplifies the impact of innovative thinking on medical science. His patents on artificial proteins with reduced immunogenicity pave the way for future advancements in therapeutic applications.