This inventor holds 1 USPTO granted patent and 1 published patent application. Top assignees: Arizona State University, Mayo Foundation for Medical Education and Research. Active years: 2020.
Company Filing History:
1 out of 2,150 
1 out of 1,804 
Years Active: 2020
Title: Innovations in Autoantibody Detection: The Contributions of Jonathan Leighton
Introduction
Jonathan Leighton is an accomplished inventor based in Scottsdale, AZ (US). He has made significant contributions to the field of medical diagnostics, particularly in the detection of autoantibodies associated with Crohn's disease. His innovative approach utilizes advanced protein array technology to enhance diagnostic accuracy and management of this complex condition.
Latest Patents
Leighton holds a patent titled "Methods for detecting novel autoantibodies in Crohn's disease." This patent focuses on the identification of autoantibodies that are useful in diagnosing and managing Crohn's disease. The innovative protein array technology employed in this patent is known as nucleic acid programmable protein arrays (NAPPA). The findings indicate that the reactivity of IgG autoantibodies was stronger than that of IgA autoantibodies. However, IgA autoantibodies demonstrated greater differential reactivity between cases and controls. Notably, four IgA autoantibodies against SNRPB, PRPH, PTTG1, and SNAI1 were newly identified, with sensitivities exceeding 15% at 95% specificity. Among these, anti-SNRPB-IgA exhibited the highest sensitivity of 24.0%. Additionally, autoantibodies associated with specific disease subtypes were discovered.
Career Highlights
Throughout his career, Jonathan Leighton has worked with prestigious organizations, including the Mayo Foundation for Medical Education and Research and Arizona State University. His work has significantly advanced the understanding of autoantibodies in relation to Crohn's disease, contributing to improved diagnostic methods.
Collaborations
Leighton has collaborated with notable professionals in his field, including Joshua LaBaer and Ji Qiu. These collaborations have further enriched his research and innovations in autoantibody detection.
Conclusion
Jonathan Leighton's contributions to the field of medical diagnostics, particularly in the detection of autoantibodies associated with Crohn's disease, highlight the importance of innovation in improving patient care. His work continues to pave the way for advancements in diagnostic technologies.