Location History:
- Cambridge, MA (US) (2015 - 2022)
- Somerville, MA (US) (2017 - 2022)
Company Filing History:
5 out of 769 
1 out of 2,961 
1 out of 2,882 
Years Active: 2015-2022
Title: Innovations by Jonathan Hoggatt in Stem Cell Research
Introduction
Jonathan Hoggatt is an accomplished inventor based in Somerville, MA (US). He has made significant contributions to the field of stem cell research, holding a total of 6 patents. His work focuses on enhancing the delivery and engraftment of stem cells, which is crucial for improving therapeutic outcomes in various medical applications.
Latest Patents
Hoggatt's latest patents include innovative methods to enhance the delivery and engraftment of stem cells. One notable patent identifies specific prostaglandin E2 receptors, particularly the EP receptor, as the key factor responsible for enhancing the homing and engraftment of hematopoietic stem and progenitor cells. His research suggests that treatment of graft sources and recipients with compounds that preferentially target the EP receptor can significantly increase engraftment success while minimizing adverse side effects associated with less selective therapies. One effective molecule used in these therapies is 5-[(1E,3R)-4,4-difluoro-3-hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5R-yl)hexyl]-2-pyrrolidinone or its pharmaceutically acceptable salt (L-902, 688). Another patent focuses on materials and methods to enhance hematopoietic stem cell engraftment procedures, detailing how in vivo treatment of a HSPC donor with compounds that reduce PGE biosynthesis or PGE receptor antagonists can increase the circulation of available HSPCs.
Career Highlights
Throughout his career, Hoggatt has worked with prestigious institutions such as Indiana University and Harvard College. His research has been pivotal in advancing the understanding of stem cell biology and improving clinical applications of stem cell therapies.
Collaborations
Hoggatt has collaborated with notable colleagues, including Louis M Pelus and Pratibha Singh, contributing to the advancement of stem cell research through shared expertise and innovative ideas.
Conclusion
Jonathan Hoggatt's contributions to stem cell research through his patents and collaborations have significantly impacted the field. His innovative approaches to enhancing stem cell engraftment are paving the way for improved therapeutic strategies in regenerative medicine.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.