Jonathan Hansen

Title: Jonathan Hansen and Prokaryotic Signaling Pathways as Logic Gates

Introduction

Jonathan Hansen is an inventor associated with ETH Zurich in Zurich, Switzerland. His patent work explores how components of prokaryotic signaling systems can be adapted to control gene expression in mammalian cells.

Latest Patents

Hansen is named on one patent, 1 patent: “Prokaryotic 2-component signaling pathways for use as logic gates in mammalian cells.” The invention describes mammalian cells containing a prokaryotic two-component signaling pathway. An activator protein activates a response regulator, which in turn activates transcription from a promoter linked to an output gene. The output gene’s expression represents one of two states: no transcription or detectable transcription. The patent also covers logic gates built from these cells and methods for integrating multiple output signals.

Career Highlights

Hansen’s listed patent reflects research at the intersection of synthetic biology, cellular engineering, and computational logic. By using signaling pathways to produce defined gene-expression states, the invention presents a framework for constructing logic gates in mammalian cells.

Collaborations

The patent’s listed collaborators include Yaakov Benenson and Krishna Kumar Swaminathan. Their work connects the invention to research on engineering biological systems and controlling cellular behavior.

Conclusion

Jonathan Hansen’s patent describes a way to use prokaryotic signaling components to create logic gates and integrate outputs in mammalian cells, highlighting the potential of synthetic biology for programmable cellular systems.