Jonathan D Violin

Title: Jonathan D Violin: Innovator in Chimeric Phosphorylation Indicators

Introduction

Jonathan D Violin is a prominent inventor based in Durham, NC (US). He is known for his significant contributions to the field of biochemistry, particularly in the development of innovative tools for studying cellular signaling pathways. His work has implications for understanding various biological processes and diseases.

Latest Patents

Jonathan D Violin holds a patent for a Chimeric Phosphorylation Indicator (CPI). This invention includes a donor molecule, a phosphorylatable domain, a phosphoaminoacid binding domain (PAABD), and an acceptor molecule. The phosphorylatable domain is designed to be phosphorylated by protein kinase C (PKC), making the CPI a c-kinase activity reporter (CKAR). The CPI can utilize fluorescent proteins as donor and acceptor molecules, allowing for advanced studies of PKC signaling pathways. The invention also encompasses polynucleotides encoding such CPIs and methods for detecting kinases or phosphatases in samples.

Career Highlights

Jonathan D Violin is affiliated with the University of California, where he continues to advance research in his field. His innovative work has led to a deeper understanding of cellular mechanisms and has opened new avenues for research and therapeutic development.

Collaborations

Some of his notable collaborators include Alexandra C Newton and Roger Y Tsien, who have contributed to the advancement of research in related areas.

Conclusion

Jonathan D Violin's contributions to the field of biochemistry, particularly through his patent on chimeric phosphorylation indicators, highlight his role as an influential inventor. His work continues to impact the scientific community and enhance our understanding of cellular signaling.