Company Filing History:
Years Active: 1990-1995
Title: Jon H. Condra: Innovator in HIV Research
Introduction
Jon H. Condra is a notable inventor based in Abington, PA (US), recognized for his contributions to the field of HIV research. With a total of 2 patents, he has made significant strides in developing innovative assays and vectors that aid in the identification and treatment of drug-resistant HIV.
Latest Patents
One of Jon H. Condra's latest patents is a color screening assay for identifying inhibitor-resistant HIV protease. This chromogenic assay is designed to identify and isolate drug-resistant HIV protease mutants. Additionally, it serves as a screening tool for new inhibitors of HIV protease that are not affected by the drug resistance of the HIV protease. The assay features a vector with a regulatable promoter that controls the transcription of two adjacent structural sequences: one coding for HIV protease or its mutant, and the other for beta-galactosidase with an amino acid substrate insert cleavable by HIV protease. Furthermore, a library of HIV proteases is described, isolated in the form of a collection of such vectors, known as a color screen vector library.
Another significant patent by Condra is a vector for the expression of fusion proteins and protein immunogens. This expression vector is characterized as a 3.35 kilobase pair vector that includes origins for replication and selectivity markers for bacteria. The plasmid features an E. coli promoter segment, a CheY fusion protein sequence, and a unique restriction site at the 3' end of the CheY segment for preparing a DNA segment that codes for a foreign protein to be expressed.
Career Highlights
Jon H. Condra is currently employed at Merck & Co., Inc., where he continues to contribute to groundbreaking research in the pharmaceutical industry. His work focuses on developing innovative solutions to combat HIV and improve treatment options for patients.
Collaborations
Throughout his career, Jon has collaborated with esteemed colleagues, including Donald J. Graham and Leah Gotlib. These partnerships have further enhanced his research and development efforts in the field of HIV.
Conclusion
Jon H. Condra's innovative work in HIV research has led to the development of valuable patents that address critical challenges in the treatment of drug-resistant HIV. His contributions continue to impact the field positively, showcasing the importance of innovation in medical research.