Company Filing History:
Years Active: 2001-2003
Title: Innovations of Johnathan Stamler in Nitrosylation of Proteins
Introduction
Johnathan Stamler is a prominent inventor based in Chapel Hill, NC (US). He has made significant contributions to the field of biochemistry, particularly in the area of protein function regulation through nitrosylation. With a total of 2 patents, his work has implications for therapeutic applications in various medical fields.
Latest Patents
Stamler's latest patents focus on the nitrosation and nitrosylation of heme proteins. His inventions enable selective regulation of protein function, enhancing the capabilities of proteins and amino acids as smooth muscle relaxants and platelet inhibitors. The novel compounds he has developed include S-nitroso-t-PA, S-nitroso-cathepsin, S-nitroso-lipoprotein, and S-nitroso-immunoglobulin. These compounds are designed for therapeutic use, aiding in the regulation of protein function, cellular metabolism, and promoting vasodilation, platelet inhibition, and relaxation of non-vascular smooth muscle. Additionally, they facilitate increased blood oxygen transport by hemoglobin and myoglobin. The compounds also serve to deliver nitric oxide in its most bioactive form, achieving the desired physiological effects.
Career Highlights
Stamler is affiliated with The Brigham and Women's Hospital, Inc., where he continues to advance research in his field. His innovative work has garnered attention and respect within the scientific community.
Collaborations
Some of his notable coworkers include Joseph Loscalzo and David J Singel, who have collaborated with him on various research projects.
Conclusion
Johnathan Stamler's contributions to the field of protein nitrosylation represent a significant advancement in biochemistry. His inventions hold promise for therapeutic applications that could improve health outcomes in numerous medical conditions.