John W Safford, Jr

Title: Innovations of John W Safford, Jr.

Introduction

John W Safford, Jr. is a notable inventor based in Wauconda, IL (US). He has made significant contributions to the field of immunoassays, holding a total of 2 patents. His work has advanced the methods used for detecting haptens and rubella antibodies, showcasing his expertise in biochemistry and immunology.

Latest Patents

Safford's latest patents include a "Hapten-inhibitor immunoassay" and a "Process for producing a soluble rubella antigen." The hapten-inhibitor immunoassay is a specific binding assay method that utilizes a reversible trypsin inhibitor for hapten detection. This method involves competition between the hapten to be determined and the hapten-trypsin inhibitor conjugate for antibody binding, followed by the addition of an enzyme substrate for effective hapten analysis. The preferred trypsin inhibitor is a protein with a molecular weight range of 2,000-75,000, and the optimal ratio of hapten to inhibitor in the conjugate is between 1:1 and 3:1. His second patent focuses on isolating a purified soluble antigen specific for the rubella virus from infected cell cultures. This antigen is characterized by its specific activity and is used in immunoassay reagents for detecting rubella antibodies in various body fluids.

Career Highlights

John W Safford, Jr. is currently associated with Abbott Laboratories Corporation, a leading company in the healthcare sector. His work at Abbott has allowed him to contribute to innovative solutions in diagnostics and immunology.

Collaborations

Some of his notable coworkers include Steven C March and Susan E Magic, who have collaborated with him on various projects within the field.

Conclusion

John W Safford, Jr. has made significant strides in the field of immunoassays through his innovative patents and contributions at Abbott Laboratories Corporation. His work continues to impact the detection and analysis of important biological markers.