Company Filing History:
Years Active: 1998
Title: John W Dubendorff: Innovator in RNA Polymerase Research
Introduction
John W Dubendorff is a notable inventor based in Sound Beach, NY (US). He has made significant contributions to the field of molecular biology, particularly in the cloning and expression of RNA polymerases. With a total of 2 patents, his work has advanced our understanding of gene expression systems.
Latest Patents
Dubendorff's latest patents focus on the cloning and expression of autogenes encoding RNA polymerases of T7 and T7-like bacteriophages. His inventions describe methods in which the RNA polymerase gene is transcribed from a promoter recognized by the encoded RNA polymerase. The cloning of T7 autogenes was achieved by reducing the activity of the RNA polymerase sufficiently to permit host cell growth. T7 RNA polymerase activity was controlled through a combination of lac-repression of the recombinant lac operator-T7 promoter in the autogene and inhibition of the polymerase by T7 lysozyme. These patents also detail expression systems for producing RNA polymerases of T7 and other T7-like bacteriophages, as well as systems for producing selected gene products.
Career Highlights
John W Dubendorff has had a distinguished career, working with Associated Universities, Inc. His research has been pivotal in the development of innovative techniques in molecular biology, particularly in the area of RNA polymerase functionality.
Collaborations
One of his notable collaborators is F William Studier, with whom he has worked on various projects related to RNA polymerases and gene expression.
Conclusion
John W Dubendorff's contributions to the field of molecular biology through his patents and research have significantly impacted the understanding of RNA polymerases. His work continues to influence advancements in genetic engineering and biotechnology.