Company Filing History:
Years Active: 2014-2020
Title: John Timothy Heap: Innovator in Genetic Engineering and Cancer Treatment
Introduction
John Timothy Heap is a notable inventor based in Nottingham, GB. He has made significant contributions to the fields of genetic engineering and cancer treatment, holding a total of 3 patents. His work focuses on innovative methods and molecules that have the potential to advance medical science.
Latest Patents
One of his latest patents involves DNA molecules and methods. This application discloses a DNA molecule comprising a modified Group II intron that does not express the intron-encoded reverse transcriptase. It contains a modified selectable marker gene in the reverse orientation, which comprises a Group I intron in forward orientation, allowing for expression in a bacterial cell of the class Clostridia. The DNA molecule also includes sequences that facilitate the insertion of the RNA transcript of the Group II intron into the chromosome of a bacterial cell of the class Clostridia. Additionally, a method for introducing a nucleic acid molecule into a specific site of a DNA molecule in a bacterial cell of the class Clostridia is provided. This DNA molecule and method are useful for creating mutations.
Another significant patent addresses a method of treatment for cancer. This invention provides a method for treating cancer in a subject by administering a prodrug. The subject is colonized with an obligate anaerobic microorganism capable of expressing a polypeptide with nitroreductase activity. This polypeptide preferentially reduces CB1954 to a 4-hydroxylamine (4HX) derivative rather than a 2-hydroxylamine derivative. The invention also includes an isolated polypeptide, nucleic acids encoding the polypeptide, vectors, and host cells containing these nucleic acids and vectors, which can be utilized in treating solid tumors.
Career Highlights
John Timothy Heap has worked with esteemed organizations such as the University of Nottingham and Morvus Technology Limited. His experience in these institutions has allowed him to develop and refine his innovative ideas, contributing to advancements in his field.
Collaborations
One of his notable collaborators is Nigel Peter Minton. Their partnership has likely fostered the development of groundbreaking research and inventions.
Conclusion
John Timothy Heap is a distinguished inventor whose work in genetic engineering and cancer treatment has the potential to make a significant impact on medical science. His innovative patents and collaborations highlight his commitment to