Company Filing History:
Years Active: 2025
Title: Innovations by John St John
Introduction
John St John is an accomplished inventor based in Brisbane, CA (US). He has made significant contributions to the field of nucleic acid methylation sequencing, holding 2 patents that address critical challenges in disease detection and analysis.
Latest Patents
His latest patents include "Methods and systems for high-depth sequencing of methylated nucleic acid." This invention improves the quality and accuracy of nucleic acid methylation sequencing, addressing limitations of bisulfite-based methods. It introduces minimally-destructive conversion methods and specialized UMI adapters, enhancing the quality of sequencing libraries and the information derived from them. This advancement allows for greater accuracy and more complete methylation-state information, which is essential for generating high-quality features for machine learning models and classifiers.
Another notable patent is "Methods and systems for detecting colorectal cancer via nucleic acid methylation analysis." This patent provides innovative methods for screening or detecting colorectal cancer and monitoring disease progression using cell-free nucleic acids. The method involves extracting DNA from a cell-free sample, converting it for methylation sequencing, and generating sequencing reads. It utilizes detection of methylation signals to train machine learning models, enabling the classification of individuals based on their health status, including healthy, cancerous, or specific disease subtypes.
Career Highlights
John St John is currently employed at Freenome Holdings, Inc., where he continues to develop groundbreaking technologies in the field of cancer detection and analysis. His work is pivotal in advancing the understanding and treatment of colorectal cancer.
Collaborations
He collaborates with talented individuals such as Steven Kothen-hill and Rui Yang, contributing to a dynamic team focused on innovative solutions in medical technology.
Conclusion
John St John is a notable inventor whose work in nucleic acid methylation sequencing has the potential to revolutionize cancer detection and treatment. His contributions are significant in the ongoing fight against colorectal cancer and highlight the importance of innovation in medical research.