John McWhirter

Title: John McWhirter: Innovator in Genetic Engineering

Introduction

John McWhirter is a notable inventor based in Sanremo, Italy. He has made significant contributions to the field of genetic engineering, particularly in the development of genetically modified mice. With a total of two patents to his name, McWhirter's work has implications for the creation of bispecific antibodies and other multispecific binding proteins.

Latest Patents

McWhirter's latest patents include innovative methods and compositions involving genetically modified mice. One patent describes mice that express a limited immunoglobulin light chain repertoire. This genetically modified mouse is characterized by a limited number of light chain variable domains. The mice present a choice of two human light chain variable gene segments, allowing for the expression of immunoglobulin light chains that comprise one of these segments. Additionally, methods for creating bispecific antibodies using these mice are provided, including the use of human light chain variable regions. Another patent focuses on non-human animals and cells that express a humanized B-cell activating factor gene, detailing methods and compositions for their use.

Career Highlights

John McWhirter is currently employed at Regeneron Pharmaceuticals, Inc., where he continues to advance his research in genetic engineering. His work at Regeneron has positioned him as a key figure in the development of innovative therapeutic solutions.

Collaborations

Some of McWhirter's notable coworkers include Lynn Macdonald and Andrew J Murphy. Their collaborative efforts contribute to the ongoing research and development initiatives at Regeneron Pharmaceuticals.

Conclusion

John McWhirter's contributions to genetic engineering through his patents and work at Regeneron Pharmaceuticals highlight his role as an innovator in the field. His research has the potential to impact therapeutic developments significantly.