Introduction: John M. Maraganore is a renowned inventor based in Charleston, Massachusetts, known for his significant contributions to the field of biotechnology. With a total of seven patents to his name, Maraganore's work primarily focuses on innovative methods for gene expression inhibition, showcasing his expertise in genetic research and pharmaceutical applications.

Latest Patents: Among his latest inventions, Maraganore has developed groundbreaking patents aimed at inhibiting the expression of specific proteins that have crucial roles in various diseases. His notable patents include:

1. **Compositions and methods for inhibition of expression of protein C (PROC) genes** - This invention relates to double-stranded ribonucleic acid (dsRNA) that specifically targets a PROC gene. It outlines methods for utilizing the dsRNA to inhibit the expression of PROC, contributing to advances in therapeutic interventions.

2. **Compositions and methods for inhibiting expression of factor V** - This invention details a double-stranded ribonucleic acid (dsRNA) designed to inhibit Factor V expression. The dsRNA comprises an antisense strand that is less than 25 nucleotides in length and is substantially complementary to parts of the Factor V gene. This patent also encompasses a pharmaceutical composition that combines the dsRNA with a pharmaceutically acceptable carrier, along with methods for treating diseases related to Factor V expression.

Career Highlights: John M. Maraganore is currently affiliated with Alnylam Pharmaceuticals, Inc., where he has played a pivotal role in the development of innovative therapies that utilize RNA interference technology. His groundbreaking work in the field of genetic medicine has positioned him as a leader in biopharmaceutical invention.

Collaborations: Maraganore collaborates with other talented professionals at Alnylam, including Ivanka Toudjarska and Brian R. Bettencourt. These partnerships enhance the research environment and foster innovation as they work together to advance biotechnological solutions.

Conclusion: John M. Maraganore’s contributions to biotechnology through his patents and ongoing research reflect the dynamic nature of innovation in the field. His work not only advances scientific knowledge but also paves the way for novel treatments that may significantly improve patient outcomes in the future.

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