John M Denu

Title: John M Denu: Innovator in Protein Research

Introduction

John M Denu is a prominent inventor based in McFarland, WI (US), known for his significant contributions to the field of protein research. With a total of 6 patents, Denu has made remarkable strides in understanding and manipulating protein functions, particularly in relation to health and disease.

Latest Patents

Denu's latest patents include groundbreaking work on Sirtuin 6 protein deacylase (SIRT6) activators. The present disclosure provides compounds according to Formula I and pharmaceutically acceptable salts thereof, as well as compositions including such compounds and a pharmaceutically acceptable carrier or excipient. Furthermore, the technology outlines methods of inactivating SIRT6 with compounds of Formula I and III, W—R—Y—R, as described herein. This innovation offers methods of treatment aimed at lowering LDL levels, reducing triglyceride levels, and increasing glucose tolerance in subjects. Additionally, it addresses the inhibition of proliferation in various cancer cells and promotes corneal epithelial wound healing.

Another notable patent involves methods for determining protein binding specificity using peptide libraries. This method allows for the determination of binding specificity for human NAD-dependent deacetylase SIRT1 and identifies the most efficiently deacetylated peptide sequences. It can also be utilized to screen a combinatorial H4 histone N-terminal tail peptide library to examine the binding preferences of a α-phos (S1) H4 antibody toward all known possible H4 histone modification states.

Career Highlights

Throughout his career, John M Denu has worked with esteemed organizations such as the Wisconsin Alumni Research Foundation and the University of Washington. His work has significantly advanced the understanding of protein functions and their implications in health.

Collaborations

Denu has collaborated with notable colleagues, including Kirk Tanner and Adam L Garske, contributing to a rich environment of innovation and research.

Conclusion

John M Denu's contributions to protein research and his innovative patents highlight his role as a leading inventor in the field. His work continues to pave the way for advancements in medical treatments and understanding of protein interactions.