John M Abrams

Title: John M Abrams: Innovator in Genetic Engineering

Introduction

John M Abrams is a notable inventor based in New York, NY (US). He has made significant contributions to the field of genetic engineering, particularly through his innovative patent related to DNA constructs.

Latest Patents

John M Abrams holds a patent for "Intronic overexpression vectors." This patent describes DNA constructs that utilize intronically positioned expression systems. In this system, one gene is a dominant gene, typically amplifiable, while the other encodes a sequence of interest. The method allows for higher levels of co-expression compared to when the genes are ligated in tandem. Specifically, the gene of interest is inserted into the intron of a DHFR minigene. The construct is then transformed into a mammalian cell, and the resulting transformants are stressed with progressively increasing levels of methotrexate. This approach leads to substantially increased levels of co-expression as methotrexate levels rise.

Career Highlights

John M Abrams is affiliated with Leland Stanford Junior University, where he continues to advance his research in genetic engineering. His work has garnered attention for its potential applications in various fields, including medicine and biotechnology.

Collaborations

Some of his notable coworkers include Robert T Schimke and Susan M Thorpe. Their collaborative efforts have contributed to the advancement of research in genetic engineering.

Conclusion

John M Abrams is a distinguished inventor whose work in genetic engineering has led to innovative solutions in the field. His patent on intronic overexpression vectors exemplifies his commitment to advancing scientific knowledge and technology.