John L Rinn

Title: John L Rinn: Innovator in Gene Expression and CRISPR Technology

Introduction

John L Rinn is a prominent inventor based in Boston, MA (US), known for his significant contributions to the field of gene expression and genetic modification. With a total of 5 patents, Rinn has made remarkable strides in understanding long non-coding RNAs (lncRNAs) and their implications in genetic research.

Latest Patents

Rinn's latest patents include a method for screening gene expression in lincRNA-deficient mice or rats. This innovation involves genetically modified non-human animals that exhibit a functional lack of one or more lncRNAs. The patents also cover methods and compositions for disrupting, deleting, and/or replacing lncRNA-encoding sequences. Additionally, he has developed genetically modified mice that age prematurely, along with cells, tissues, and embryos that are genetically modified to comprise a loss-of-function of one or more lncRNAs. Another notable patent focuses on methods of making and using guide RNA for use with Cas9 systems, providing CRISPR/Cas systems where guide RNAs include one or more selected RNA sequences for delivery to a target nucleic acid sequence.

Career Highlights

Throughout his career, Rinn has worked with prestigious institutions such as Harvard College and the University of Pennsylvania. His research has significantly advanced the understanding of genetic mechanisms and their applications in various fields.

Collaborations

Rinn has collaborated with notable colleagues, including Brian Gregory and Fan Li, contributing to a rich exchange of ideas and innovations in genetic research.

Conclusion

John L Rinn's work in gene expression and CRISPR technology exemplifies the impact of innovative research on genetic science. His patents and collaborations continue to influence the field and pave the way for future advancements.