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Title: The Innovative Contributions of John Karanicolas
Introduction
John Karanicolas is a notable inventor based in St. Lawrence, Kansas, who has made significant contributions to the field of peptide design. With a focus on developing methods to inhibit amyloid fibrillation, Karanicolas has one patent to his name, showcasing his expertise and innovative spirit.
Latest Patents
Karanicolas holds a patent titled "Structure-based design of peptide inhibitors of amyloid fibrillation." This invention provides methods for designing peptides that inhibit aggregation in target polypeptides. The candidate inhibitory peptidic compounds feature an oligomeric sequence that forms energetically favorable interactions with the amino acid sequence of the steric zipper region of the target protein. Additionally, these compounds possess a zipper-disrupting feature that disrupts peptide stacking at the steric zipper region. This method can be utilized to obtain inhibitory peptides that disrupt fibril formation involving any protein for which a steric zipper sequence can be identified. The invention also includes inhibitory peptidic compounds that can be used in pharmaceutical compositions and methods for treating polypeptide aggregation-associated diseases or conditions.
Career Highlights
Throughout his career, Karanicolas has worked at prestigious institutions, including the University of California and the University of Washington. His work has focused on advancing the understanding of peptide interactions and their implications in various diseases.
Collaborations
Karanicolas has collaborated with esteemed colleagues, including David S. Eisenberg and Stuart A. Sievers, contributing to the advancement of research in his field.
Conclusion
John Karanicolas is a distinguished inventor whose work in peptide design has the potential to impact the treatment of diseases associated with protein aggregation. His innovative methods and collaborations highlight his commitment to advancing scientific knowledge and improving health outcomes.