The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 17, 2014
Filed:
Feb. 08, 2010
David S. Eisenberg, Los Angeles, CA (US);
Stuart A. Sievers, Van Nuys, CA (US);
John Karanicolas, St. Lawrence, KS (US);
David Baker, Seattle, WA (US);
David S. Eisenberg, Los Angeles, CA (US);
Stuart A. Sievers, Van Nuys, CA (US);
John Karanicolas, St. Lawrence, KS (US);
David Baker, Seattle, WA (US);
The Regents of the University of California, Oakland, AL (US);
University of Washington, Seattle, WA (US);
Abstract
The invention provides methods for designing peptides that inhibit aggregation in target polypeptides. The candidate inhibitory peptidic compounds have an oligomeric sequence that forms energetically-favorable interactions with the amino acid sequence of the steric zipper region of the target protein, and also possess a zipper-disrupting feature that disrupt the peptide stacking at the steric zipper region. This method can be used to obtain inhibitory peptides to disrupt fibril formation involving any protein for which a steric zipper sequence can be identified. The invention also provides inhibitory peptidic compounds, which can be used in pharmaceutical compositions and methods for treating polypeptide aggregation-associated diseases or conditions.