Company Filing History:
Years Active: 1981-1991
Title: John K Daniel: Innovator in Carbohydrate Digestive Enzyme Inhibition
Introduction
John K Daniel is a notable inventor based in Indianapolis, IN (US). He has made significant contributions to the field of biochemistry, particularly in the development of compounds that inhibit carbohydrate digestive enzymes. With a total of 6 patents, his work has implications for treating diabetes and advancing pharmaceutical research.
Latest Patents
Among his latest patents, Daniel has developed compounds such as Castanospermine esters and glycosides. These compounds are described as active inhibitors of carbohydrate digestive enzymes and are useful in treating diabetes. The preparation of these compounds involves the reaction of castanospermine with appropriate acid halides or anhydrides, as well as glycosyl halides or glycosyl acetimidates. The process allows for the selective formation of mono- and di-esterified and glycosylated products, utilizing various blocking groups that can be removed under mild conditions.
Another significant patent involves a process for hydrolyzing 2,6-dideoxy-2,6-iminoheptononitrile derivatives. This procedure outlines a mild conversion of a carbonitrile to the corresponding carboxylic acid using trifluoroacetic acid in the presence of a catalytic amount of mercuric ion, followed by oxidative hydrolysis with dinitrogen tetroxide. This method is also applied in the preparation of specific chemical compounds, showcasing Daniel's innovative approach to chemical synthesis.
Career Highlights
Throughout his career, John K Daniel has worked with prominent companies such as The Dow Chemical Company and Merrell Dow Pharmaceuticals. His experience in these organizations has contributed to his expertise in the field of pharmaceuticals and chemical engineering.
Collaborations
Daniel has collaborated with notable coworkers, including Norton P Peet and Paul S Liu. These partnerships have likely enhanced his research and development efforts, leading to impactful innovations in his field.
Conclusion
John K Daniel's contributions to the field of biochemistry and his innovative patents demonstrate his commitment to advancing medical science. His work continues to influence the development of treatments for diabetes and other related conditions.