This inventor holds 3 USPTO granted patents. Top assignee: Gilead Sciences, Inc.. Active years: 1996-1998.
Company Filing History:
Years Active: 1996-1998
Title: Innovations of John J Toole
Introduction
John J Toole is a notable inventor based in Burlingame, CA (US). He has made significant contributions to the field of biomolecular research, particularly through his innovative patents. With a total of 3 patents, Toole's work has implications for therapeutic, diagnostic, and manufacturing purposes.
Latest Patents
Toole's latest patents include groundbreaking advancements in aptamer technology. One of his patents focuses on "Aptamer analogs specific for biomolecules," which discloses oligonucleotide sequences that mediate specific binding to selected target molecules. These sequences contain modified bases, sugars, or sugar linkages, allowing for the generation of binding oligomers that can target a wide range of biomolecules composed of amino acids, lipids, and carbohydrates. This versatility makes them useful in various applications, including therapeutics and diagnostics.
Another significant patent is titled "Aptamers specific for biomolecules and methods of making." This patent describes a method for identifying oligomer sequences that specifically bind to target molecules such as serum proteins and kinins. The technique involves complexation of the target molecule with a mixture of oligonucleotides, followed by separation and recovery of the complexed members using polymerase chain reaction. The resulting oligonucleotides can be utilized for therapeutic and diagnostic purposes.
Career Highlights
John J Toole is currently associated with Gilead Sciences, Inc., where he continues to advance his research in biomolecular applications. His work has positioned him as a key figure in the field, contributing to the development of innovative solutions that address complex biological challenges.
Collaborations
Toole has collaborated with notable colleagues, including John A Latham and Linda C Griffin. These partnerships have fostered a collaborative environment that enhances the potential for groundbreaking discoveries in their shared field of expertise.
Conclusion
John J Toole's contributions to biomolecular research through his patents and collaborations highlight his role as an influential inventor. His work continues to pave the way for advancements in therapeutic and diagnostic applications.