Company Filing History:
Years Active: 1999-2006
Title: John J Ngai: Innovator in RNA Technologies
Introduction
John J Ngai is a prominent inventor based in Berkeley, CA (US). He has made significant contributions to the field of molecular biology, particularly in the area of RNA technologies. With a total of 7 patents to his name, Ngai's work has advanced our understanding and manipulation of RNA.
Latest Patents
One of Ngai's latest patents is focused on normalizing and amplifying RNA. This invention provides methods and compositions for normalizing and amplifying RNA populations. The methods generally comprise the steps of copying message RNA (mRNA) to form first single-stranded (ss) cDNA, converting the first ss-cDNA to first double-stranded (ds) cDNA, and linearly amplifying the first ds-cDNA to form first amplified RNA (aRNA). Additionally, it involves tagging the 3' end of the first aRNA with a known sequence to form 3′-tagged first aRNA, copying the 3′-tagged first aRNA to form second ss-cDNA, and normalizing the mRNA and/or the first aRNA.
Another notable patent involves methods for making nucleic acids. This patent describes the process of converting a primed single-stranded DNA to a double-stranded DNA. The method includes contacting the single-stranded DNA with a DNA polymerase having 5′ exonuclease activity under specific conditions, allowing the DNA polymerase to convert the single-stranded DNA to double-stranded DNA.
Career Highlights
John J Ngai is affiliated with the University of California, where he conducts his research and development. His work has been instrumental in pushing the boundaries of RNA research, making significant strides in the field.
Collaborations
Ngai has collaborated with notable colleagues, including Tito A Serafini and David W Lin. These partnerships have further enriched his research and contributed to the advancements in RNA technologies.
Conclusion
John J Ngai is a distinguished inventor whose work in RNA technologies has led to several important patents. His contributions continue to influence the field of molecular biology and enhance our understanding of RNA manipulation.
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