John Giddens

Title: Innovations of John Giddens in Glycoprotein Synthesis

Introduction

John Giddens is an accomplished inventor based in Chesapeake, VA (US). He has made significant contributions to the field of glycoprotein synthesis, particularly through his innovative patent that focuses on core fucosylated glycopeptides and glycoproteins. His work has implications in various biotechnological applications.

Latest Patents

John Giddens holds a patent titled "Core fucosylated glycopeptides and glycoproteins: chemoenzymatic synthesis and uses thereof." This patent describes a chemoenzymatic method for preparing core-fucosylated glycoproteins or glycopeptides. The process involves providing an acceptor, which can be a fucosylated GlcNAc-protein or fucosylated GlcNAc-peptide, and reacting it with a donor substrate that includes an activated oligosaccharide moiety. The method utilizes an endoglycosidase (ENGase) to transfer the oligosaccharide moiety to the acceptor, resulting in the desired glycoprotein or glycopeptide structure. Additionally, the patent outlines methods for remodeling fucosylated glycoproteins or glycopeptides with predetermined natural N-glycans or tailor-made oligosaccharide moieties.

Career Highlights

John Giddens is affiliated with the University System of Maryland, where he continues to advance research in glycoprotein synthesis. His innovative approaches have garnered attention in the scientific community, contributing to the understanding and application of glycoproteins in various fields.

Collaborations

John has collaborated with notable researchers such as Lai-Xi Wang and Wei Huang. These collaborations have further enriched his research and expanded the impact of his work in glycoprotein synthesis.

Conclusion

John Giddens is a prominent inventor whose work in glycoprotein synthesis has led to significant advancements in the field. His innovative patent and collaborations highlight his contributions to biotechnology and the scientific community.