John E Piletz

Title: John E Piletz: Innovator in Receptor Biology and Therapeutics

Introduction

John E Piletz is a notable inventor based in Madison, MS (US), recognized for his contributions to the field of receptor biology and therapeutic innovations. With a total of six patents to his name, Piletz has made significant strides in understanding and manipulating biological receptors for medical applications.

Latest Patents

Among his latest patents, Piletz has developed a cDNA encoding a human imidazoline receptor, which includes a ligand binding assay employing the same. This invention describes the amino acid sequence of the entire imidazoline receptor protein and identifies a C-terminal fragment believed to contain the imidazoline binding site. The uniqueness of this protein's sequence suggests it may represent the first in a novel family of receptor proteins. Additionally, he has created a screening method for identifying drugs that interact with the imidazoline receptor. Another significant patent involves a mammalian agmatinase inhibitory substance, which provides methods and compounds for treating various brain trauma and disorders, including ischemia, stroke, neurodegenerative disorders, opioid addiction, idiopathic pain, epilepsy, and depression.

Career Highlights

Piletz has had a distinguished career, working at prominent institutions such as the University of Mississippi and Jackson State University. His research has focused on the development of innovative therapeutic strategies that address critical health issues.

Collaborations

Throughout his career, Piletz has collaborated with esteemed colleagues, including Tina R Ivanov and Ming-Ju Huang, contributing to a rich exchange of ideas and advancements in their respective fields.

Conclusion

John E Piletz stands out as a significant figure in the realm of receptor biology and therapeutic innovation. His patents reflect a commitment to advancing medical science and improving treatment options for various disorders.