Location History:
- Santa Clara, CA (US) (2012)
- Los Gatos, CA (US) (2013)
Company Filing History:
3 out of 5,309 
1 out of 11 Years Active: 2012-2013
Title: Innovations of John E Kirkwood in Collagen Gel Technology
Introduction
John E Kirkwood is a notable inventor based in Santa Clara, CA (US), recognized for his contributions to the field of biomaterials. He holds a total of 3 patents, focusing primarily on the production and application of collagen gels. His work has significant implications for various industrial applications, particularly in tissue engineering and regenerative medicine.
Latest Patents
One of Kirkwood's latest patents involves the development of oriented collagen gels. This innovative technique utilizes hydrodynamics to influence the assembly of collagen fibers. Highly concentrated monomeric solutions of collagen are subjected to shear and extensional flow, which induces fibrillogenesis under a high pH buffer. The resulting gel captures the flow-induced ordering of molecular collagen during fibril formation. Notably, the induction of fibrillogenesis occurs without the need for a magnetic field. These highly oriented 3D scaffolds are capable of inducing contact guidance and promoting mammalian cell growth. The collagen fibers produced mimic the structure of in vivo fibers, exhibiting characteristic D-periodicity, which is crucial for the response of integrin receptors on fibroblasts. The industrial applications of these three-dimensional collagen gels as biomaterials are extensive, ranging from drug delivery systems to burn repair and tissue engineering.
Career Highlights
Throughout his career, John E Kirkwood has worked with esteemed institutions, including Leland Stanford Junior University and Fibralign Corporation. His research and innovations have positioned him as a key figure in the development of advanced biomaterials.
Collaborations
Kirkwood has collaborated with notable professionals in his field, including Gerald G Fuller and Mikhail Vitoldovich Paukshto. These collaborations have further enhanced the impact of his work in the realm of collagen gel technology.
Conclusion
John E Kirkwood's innovative contributions to collagen gel technology have paved the way for advancements in biomaterials, with significant potential for applications in medicine and tissue engineering. His work continues to influence the field and inspire future research.