John E Coligan

Title: John E Coligan: Innovator in Immunology and Viral Treatment

Introduction

John E Coligan is a prominent inventor based in Potomac, MD (US), known for his significant contributions to the fields of immunology and viral treatment. With a total of 2 patents, Coligan has developed innovative methods that aim to enhance immune response management and combat viral infections.

Latest Patents

Coligan's latest patents include groundbreaking work on the induction of antigen-specific unresponsiveness by glioblastoma culture supernatants (GCS). This invention focuses on methods to specifically inhibit an immune response to selected antigens using an immunosuppressive composition derived from a glioblastoma cell line. The method involves obtaining a population of antigen presenting cells (APCs), loading them with specific antigens, and introducing the incubated cells into the subject being treated. This approach aims to induce apoptosis and/or anergy in T cells specific for the antigens present on the APCs, thereby selectively inhibiting the immune response.

Another notable patent by Coligan involves methods and compositions for the inhibition of viral replication. This invention provides methods for treating viral infections by inhibiting the activity of host cellular enzymes. It includes casein kinase II inhibitors and related compounds that target cellular proteins to effectively reduce viral replication.

Career Highlights

Coligan is affiliated with the National Institutes of Health, a component of the US Department of Health & Human Services. His work at this esteemed institution has allowed him to contribute to vital research in immunology and viral treatment, further establishing his reputation as an innovator in these fields.

Collaborations

Coligan has collaborated with notable colleagues such as James W Critchfield and Thomas M Folks, enhancing the impact of his research through teamwork and shared expertise.

Conclusion

John E Coligan's innovative patents and contributions to immunology and viral treatment highlight his role as a leading inventor in the scientific community. His work continues to influence the development of new therapeutic strategies for managing immune responses and viral infections.