Location History:
- Seattle, WA (US) (2006)
- Parkville, MO (US) (2007 - 2008)
Company Filing History:
Years Active: 2006-2008
Title: Innovations in Immunology: The Contributions of John D. Pluenneke
Introduction
John D. Pluenneke, based in Parkville, MO, is a renowned inventor with a focus on advancements in immunology. With a total of three patents to his name, his work primarily revolves around innovative treatments for medical conditions associated with interleukin-4.
Latest Patents
Pluenneke's recent patents relate to methods and compositions involving anti-interleukin-4 receptor antibodies. These inventions outline approaches for treating various medical conditions induced by interleukin-4 through administering IL-4 antagonists. Suitable antagonists include IL-4 receptors, antibodies that bind IL-4 and IL-4 receptor (IL-4R), as well as IL-4 muteins which do not trigger a biological response. His patents also describe molecules that inhibit IL-4-induced signal transduction, thereby preventing the biological effects of IL-4 on cell surface IL-4R. Notably, his methodology includes the generation of human monoclonal antibodies through immunizing transgenic mice, with certain antibodies exhibiting the capability to inhibit both IL-4 and IL-13 induced biological activities.
Career Highlights
Throughout his career, John D. Pluenneke has made significant contributions to the field of immunology, particularly through his association with Immunex Corporation. His groundbreaking research has facilitated advancements in therapeutic solutions for patients affected by immunological disorders, highlighting the importance of targeted treatments in modern medicine.
Collaborations
Pluenneke has collaborated with notable colleagues such as Kendall M. Mohler and Dauphine S. Barone. Together, they have worked on projects that utilize innovative approaches to develop treatments that harness the potential of antibodies against interleukin-4, showcasing the strength of teamwork in scientific discovery and innovation.
Conclusion
John D. Pluenneke’s inventive work within the realm of anti-interleukin-4 receptor antibodies is a testament to his commitment to advancing medical technologies. His contributions not only enrich the field of immunology but also provide hope for effective treatments for various health conditions. As a leader in this niche area, Pluenneke continues to inspire future innovations that pave the way for enhanced patient care.