Company Filing History:
Years Active: 2004-2005
Title: Innovations and Contributions of Inventor John D. McNeish
Introduction: John D. McNeish, based in Mystic, Connecticut, is a notable inventor with two patents to his name. His work primarily focuses on genetic modifications and animal models that contribute to biomedical research, particularly in the realm of neurodegenerative diseases. McNeish's inventions provide valuable insights into mechanisms that underpin conditions like Alzheimer's disease.
Latest Patents: McNeish's latest patents showcase his innovative contributions to the field. The first patent, titled "Modulating Ramp Activity," involves genetically-modified non-human mammals along with animal cells featuring a disrupted RAMP1, RAMP2, or RAMP3 gene. This invention encompasses methods for screening agents that can influence the activity or expression of a RAMP and offers potential treatments for modulating liver function and muscle metabolism.
The second patent, "Transgenic Mice Expressing Human p25," represents a significant advancement in creating a model for Alzheimer's disease. This invention includes transgenic, non-human animals and cells that harbor a transgene encoding a p25 polypeptide, crucial for activating the protein kinase cdk5. McNeish's work demonstrates that by overexpressing human p25 in transgenic mice, it is possible to replicate tau pathology associated with Alzheimer's disease, providing a crucial tool for research into the condition.
Career Highlights: John D. McNeish has made remarkable strides in biomedical research through his position at Pfizer Corporation. His focus on genetic modifications and animal models highlights his commitment to understanding and developing treatments for neurological disorders. His patents contribute significantly to the scientific community's efforts to tackle complex diseases like Alzheimer's.
Collaborations: Throughout his career, McNeish has collaborated with notable figures in the field, including Michael K. Ahlijanian and Walter C. Soeller. These partnerships have enhanced his research efforts and facilitated the advancement of innovative solutions to pressing health issues.
Conclusion: John D. McNeish continues to be a significant figure in the realm of biomedical innovation. His patented technologies not only push the boundaries of genetic research but also provide pivotal resources for understanding and treating devastating diseases like Alzheimer's. The ongoing impact of his work at Pfizer Corporation exemplifies the importance of innovation in improving human health.