John C Roberts

Title: John C Roberts: Innovator in Sulfonic Acid Protecting Groups

Introduction

John C Roberts is a notable inventor based in Newton, MA (US). He has made significant contributions to the field of organic chemistry, particularly in the area of sulfonic acid functional groups. His innovative approach has led to advancements that enhance the bioavailability of drugs.

Latest Patents

John C Roberts holds 1 patent for his invention titled "Formation and utility of sulfonic acid protecting groups." This patent describes a method for protecting a sulfonic acid functional group in an organic molecule as a substituted or unsubstituted neopentyl sulfonate ester. The method allows for the conversion of R--SO.sub.3 --H to R'--SO.sub.3 --H, where R and R' are different organic radicals. Additionally, the patent discloses a method to increase the bioavailability of drugs containing a sulfonic acid functional group by utilizing a substituted neopentyl sulfonate ester that has a masked heteroatom nucleophile. This masked nucleophile can be liberated in vivo, leading to the removal of the neopentyl protecting group and the regeneration of the parent drug.

Career Highlights

John C Roberts is currently associated with Procept Corporation, where he continues to apply his expertise in organic chemistry. His work has been instrumental in developing methods that improve drug formulations and their effectiveness.

Collaborations

One of his notable coworkers is Raymond J Patch, with whom he has likely collaborated on various projects within the realm of organic chemistry and drug development.

Conclusion

John C Roberts is a distinguished inventor whose work on sulfonic acid protecting groups has the potential to significantly impact the pharmaceutical industry. His innovative methods enhance drug bioavailability, showcasing the importance of his contributions to organic chemistry.