John B McArthur

Title: Innovations of John B McArthur

Introduction

John B McArthur is a notable inventor based in Davis, California. He has made significant contributions to the field of biochemistry, particularly in the development of sialyltransferase variants and heparosan synthases. With a total of two patents to his name, McArthur's work has implications for various applications in biotechnology and medicine.

Latest Patents

One of McArthur's latest patents focuses on sialyltransferase variants having neosialidase activity. This patent describes α2-6-Sialyltransferase (2,6ST) variants that exhibit improved α2-6-specific sialidase activity compared to native 2,6ST enzymes. The variants include GT80 sialyltransferases such as Pd2,6ST. Additionally, methods for producing de-sialylated products and screening sialidase activity are outlined in this patent. Another significant patent involves heparosan synthases, which are variants that demonstrate improved expression levels, enhanced thermal stability, and reduced reverse glycosylation activity. This patent also describes methods for synthesizing oligosaccharides and polysaccharides, including heparin analogs and heparan sulfate analogs.

Career Highlights

John B McArthur is affiliated with the University of California, where he continues to advance research in his field. His work has garnered attention for its innovative approaches to enzyme engineering and carbohydrate synthesis.

Collaborations

McArthur has collaborated with notable colleagues, including Xi Chelsea Chen and Andrew J Fisher. These collaborations have contributed to the advancement of research in biochemistry and related fields.

Conclusion

John B McArthur's contributions to the field of biochemistry through his patents and collaborations highlight his role as an influential inventor. His work continues to pave the way for advancements in biotechnology and medicine.