This inventor holds 4 USPTO granted patents and 2 published patent applications, plus 3 CIPO patents and 2 EPO patents. Top assignees: Crucell Holland B.v., Janssen Vaccines & Prevention B.v.. Active years: 2013-2019.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 2013-2019
Title: Innovations of John Alfred Lewis
Introduction
John Alfred Lewis is a notable inventor based in Little Compton, Rhode Island, who has made significant contributions to the field of virology. With a total of four patents to his name, Lewis has focused on developing innovative methods for viral attenuation and vector production.
Latest Patents
Among his latest patents is the Cold-adapted-viral-attenuation (CAVA) method, which involves attenuating a poliovirus strain through a novel approach. The resulting recombinant attenuated poliovirus, known as CAVA-PV, demonstrates wild-type replication at 30°C, while showing no substantial replication at 37°C. This unique characteristic is defined by the inability to quantify the virus during infection at the higher temperature through various methods, including titration, qPCR, and Electron Microscopy. CAVA-PV is genetically stable under production conditions and serves as a backbone for producing attenuated strains with the same antigenic profile as conventional vaccines. Additionally, mutations identified in CAVA-PV can be engineered into different poliovirus strains to create new CAVA-PV variants. Another significant patent involves a method for the large-scale production of recombinant adenovirus 35, utilizing perfusion systems and high-cell density infections.
Career Highlights
Throughout his career, John Alfred Lewis has worked with prominent companies in the biotechnology sector, including Crucell Holland B.V. and Janssen Vaccines & Prevention B.V. His work has contributed to advancements in vaccine development and viral research.
Collaborations
Lewis has collaborated with notable colleagues, including Alfred Luitjens and Barbara Petronella Sanders, further enhancing the impact of his innovations in the field.
Conclusion
John Alfred Lewis's contributions to virology through his innovative patents and collaborations have significantly advanced the understanding and production of viral vaccines. His work continues to influence the field and pave the way for future developments.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile