Company Filing History:
Years Active: 2001-2005
Title: The Innovative Contributions of John A. Wickersham in Biochemistry
Introduction
John A. Wickersham, an accomplished inventor based in Escondido, California, has made significant strides in the field of biochemistry, particularly through his work with vascular endothelial growth factor receptor 2 (VEGFR2/KDR). With a total of five patents to his name, his innovative contributions are paving the way for new therapeutic approaches in treating various medical conditions.
Latest Patents
Among his latest patents, Wickersham's work on the modifications of the VEGF receptor-2 protein stands out. This invention involves a 2.4 Å crystal structure of a protein construct containing the catalytic kinase domain of VEGFR2/KDR. The novel protein construct incorporates a modified catalytic linker while maintaining comparable in vitro kinase activity to constructs containing the entire KID. The key advancement allows for complete crystallization of the protein, making it accessible for characterization by X-ray crystallography. Wickersham's patent also discusses the utilization of the crystallographic data in identifying and constructing potential therapeutic compounds aimed at treating diverse disease conditions.
Career Highlights
Wickersham works at Agouron Pharmaceuticals, Inc., where he has honed his skills and contributed to groundbreaking research and development efforts. His focus on the biochemical pathways involved in angiogenesis has positioned him as a leading figure in his field, demonstrating how innovative research can lead to practical applications in medicine.
Collaborations
Throughout his career, Wickersham has collaborated with talented individuals, including Michele Ann McTigue and Chris Pinko. These partnerships have enriched his research and spurred further innovations. Working alongside such proficient colleagues has enabled the advancement of complex projects that hold immense potential for medical breakthroughs.
Conclusion
John A. Wickersham's inventive spirit and dedication to biochemistry exemplify the transformative power of innovation in science and medicine. His contributions, particularly regarding the VEGF receptor-2 protein, are not only enhancing our understanding of angiogenesis but also leading towards the development of effective therapeutic strategies. As a prominent figure in the realm of biochemistry, Wickersham's work continues to inspire future generations of inventors and researchers.