Jim Broach

Title: Jim Broach: Innovator in Yeast Cell Engineering

Introduction

Jim Broach is a notable inventor based in Princeton, NJ (US), recognized for his contributions to the field of biotechnology. He holds a total of six patents, showcasing his innovative approach to scientific challenges. His work primarily focuses on engineering yeast cells to produce pheromone system protein surrogates, which has significant implications in various applications.

Latest Patents

Among his latest patents, Jim Broach has developed yeast cells engineered to express surrogates of pheromone system proteins. These proteins include enzymes involved in the maturation of α-factor, transporters of a-factor, and pheromone receptors. The engineered yeast cells are designed to express both the surrogate and a potential peptide modulator, allowing for the inhibition or activation of the surrogate to affect a screenable or selectable trait of the yeast cells. This innovative approach improves the signal-to-noise ratio of the screening and selection system, enhancing the efficiency of the process.

Career Highlights

Throughout his career, Jim Broach has worked with prominent companies such as Cadus Pharmaceutical Corp. and Cadus Technologies, Inc. His experience in these organizations has contributed to his expertise in yeast cell engineering and biotechnology.

Collaborations

Jim has collaborated with notable colleagues, including Dana M. Fowlkes and John P. Manfredi. These partnerships have further enriched his research and development efforts in the field.

Conclusion

Jim Broach's innovative work in yeast cell engineering and his numerous patents highlight his significant contributions to biotechnology. His advancements in producing pheromone system protein surrogates pave the way for future research and applications in the field.