Cadus Technologies, Inc.

Cadus Pharmaceutical Corp.

Jim Broach

Andrew J Murphy

Joshua Trueheart

Dana M Fowlkes

John P Manfredi

Jeremy I Paul

Christine A Klein

Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of &#x3b1;-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that the inhibition or activation of the surrogate affects a screenable or selectable trait of the yeast cells. Various additional features improve the signal-to-noise ratio of the screening/selection system.

Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor

Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of .alpha.-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that the inhibition or activation of the surrogate affects a screenable or selectable trait of the yeast cells. Various additional features improve the signal-to-noise ratio of the screening/selection system.

Yeast cells engineered to produce pheromone system protein surrogates,

Yeast cells engineered to produce pheromone system protein surrogates

Growing community of inventors

Princeton, NJ, United States of America

Jim Broach