Jiegen Liu

Title: Jiegen Liu: Innovator in Pharmaceutical Synthesis

Introduction

Jiegen Liu is a notable inventor based in Zhejiang, China, recognized for his contributions to pharmaceutical synthesis. He holds 2 patents that showcase his innovative methods in drug preparation, particularly in the synthesis of important pharmaceutical compounds.

Latest Patents

One of Liu's latest patents is a method for preparing apremilast, a compound used in the treatment of various inflammatory conditions. This method involves reacting (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine N-acetyl-L-leucine salt with 3-acetylaminophthalic anhydride in an aprotic solvent. The process is designed to be cost-effective, utilizing inexpensive raw materials and reagents, making it suitable for industrial production with significant economic benefits.

Another significant patent by Liu is related to the synthesis of a voriconazole intermediate. This method emphasizes mild and controllable reaction conditions, which help reduce impurities and eliminate the use of highly toxic metals, ensuring a higher purity product with substantial industrial application value.

Career Highlights

Jiegen Liu is currently employed at Zhejiang Huahai Pharmaceutical Co., Ltd., where he applies his expertise in pharmaceutical chemistry. His work focuses on developing efficient and safe methods for drug synthesis, contributing to the advancement of the pharmaceutical industry.

Collaborations

Liu collaborates with talented colleagues, including Xiaoqiu Du and Lianchao Zhou, to enhance the research and development efforts at their company. Their teamwork fosters an environment of innovation and progress in pharmaceutical research.

Conclusion

Jiegen Liu's innovative approaches to drug synthesis have made a significant impact in the pharmaceutical field. His patents reflect a commitment to improving production methods while ensuring safety and efficacy in drug development.