The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2020
Filed:
Jan. 16, 2017
Zhejiang Huahai Pharmaceutical Co., Ltd, Zhejiang, CN;
Hu Huang, Zhejiang, CN;
Wenfeng Huang, Zhejiang, CN;
Guoliang Tu, Zhejiang, CN;
Jiegen Liu, Zhejiang, CN;
Zhongming Xu, Zhejiang, CN;
Qianghui Wu, Zhejiang, CN;
Zhaoyang Meng, Zhejiang, CN;
Yuling Fang, Zhejiang, CN;
ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD., Zhejiang, CN;
Abstract
Provided is a synthesis method for a voriconazole intermediate condensate as shown in formula II or an acid addition salt thereof. As shown in reaction formula 1, the product is prepared via compounds III and IV. The synthesis method adjusts the feeding means, and the reaction conditions are mild and controllable, thereby reducing the production of impurity A, avoiding the use of highly toxic metal lead, and eliminating the risk of highly toxic metal remaining in a drug. The product has a higher purity and significant industrial application value.