This inventor holds 1 USPTO granted patent and 1 EPO patent. Top assignees: Enzo Biochem, Inc., St. Jude's Childrens Hospital, University of Connecticut. Active years: 2014.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
1 out of 81 
1 out of 1 
1 out of 785 
Years Active: 2014
Title: Innovations in Bone Formation: The Contributions of Jie Zhang
Introduction
Jie Zhang is an accomplished inventor based in Memphis, TN (US). He has made significant contributions to the field of bone formation and remodeling through his innovative research and patents. His work has implications for understanding bone health and potential treatments for related conditions.
Latest Patents
Jie Zhang holds a patent titled "Compositions and methods for bone formation and remodeling." This patent investigates the mechanism by which the high bone mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates canonical Wnt signaling. The research reveals that the G171V mutation disrupts the interaction of LRP5 with Mesd, a chaperone protein necessary for the transport of LRP5/6 to cell surfaces. This disruption results in fewer LRP5 molecules on the cell surface, leading to a reduction in Wnt signaling in a paracrine paradigm. However, the mutation does not appear to affect the activity of coexpressed Wnt in an autocrine paradigm. The findings suggest that the G171V mutation may increase Wnt activity in osteoblasts by reducing the number of targets for paracrine Dkk1 to antagonize without affecting the activity of autocrine Wnt.
Career Highlights
Throughout his career, Jie Zhang has worked with notable organizations, including Enzo Biochem, Inc. and the University of Connecticut. His experience in these institutions has allowed him to collaborate with other experts in the field and contribute to advancements in bone health research.
Collaborations
Jie Zhang has collaborated with esteemed colleagues such as Dean L Engelhardt and Dianqing Wu. These partnerships have enriched his research and expanded the impact of his work in the scientific community.
Conclusion
Jie Zhang's innovative research and patent contributions have significantly advanced the understanding of bone formation and remodeling. His work continues to influence the field and holds promise for future developments in bone health.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile