Jiasheng Wu

Title: Innovations of Jiasheng Wu in Hypocrellin Derivatives

Introduction

Jiasheng Wu is a prominent inventor based in Beijing, China. He has made significant contributions to the field of photosensitizers through his innovative work on hypocrellin derivatives. With a total of two patents to his name, his research focuses on enhancing the efficacy of these compounds in medical applications.

Latest Patents

Wu's latest patents include a hypocrellin derivative substituted both in a peri-position and in 2-position by amino, along with its preparation method and applications. This invention reveals that the derivative has a maximum absorption wavelength of 600-650 nm and a molar extinction coefficient reaching about 20000-40000 Mcm. Compared to unmodified hypocrellin, this derivative shows a significantly red-shifted absorption spectrum and improved molar extinction coefficient, allowing it to efficiently produce reactive oxygen species, such as singlet oxygen, under photosensitive conditions. Furthermore, when used as a photosensitizer, it demonstrates a stronger ability to photodynamically inactivate tumor cells than first and second generation commercial photosensitizers.

Another notable patent by Wu is the development of a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, along with its preparation method and applications. This derivative, substituted by a group containing PEG or a quaternary ammonium salt, exhibits a red shift in its absorption spectrum and a significantly enhanced molar extinction coefficient compared to the parent hypocrellin. It can efficiently produce singlet state oxygen and other reactive oxygen species under photosensitive conditions. Additionally, this derivative offers different amphiphilicities and increased biocompatibility with cells or tissues, meeting the requirements of various clinical drugs and drug delivery methods.

Career Highlights

Jiasheng Wu is affiliated with the Chinese Academy of Sciences, where he conducts his research. His work has garnered attention for its potential applications in cancer treatment and other medical fields. His innovative approach to modifying hypocrellin derivatives has positioned him as a key figure in the development of advanced photosensitizers.

Collaborations

Wu collaborates with notable colleagues, including Pengfei Wang and Weimin Liu, who contribute to his research endeavors. Their combined expertise enhances the quality and impact of their work in the field of photosensitizers.

Conclusion

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