Company Filing History:
Years Active: 1997-2002
Title: Innovations and Contributions of Jian-ping Xiao
Introduction
Jian-ping Xiao is a notable inventor based in Wenham, MA (US). He has made significant contributions to the field of biotechnology, particularly in the area of recombinant DNA technology. With a total of 8 patents, his work has advanced the understanding and application of restriction endonucleases.
Latest Patents
One of Jian-ping Xiao's latest patents is a method for cloning and expression of Bpml restriction endonuclease in E. coli. This invention relates to recombinant DNA that encodes the BpmI restriction endonuclease and BpmI methyltransferase, facilitating the expression of BpmI restriction endonuclease from cells containing the recombinant DNA. The BpmI endonuclease is a fusion of two distinct elements with a possible structural domain of restriction-methylation-specificity (R-M-S). This domain organization is analogous to the type I restriction-modification system, which includes three distinct subunits: restriction, methylation, and specificity (R, M, and S). BpmI is distinct from other type IIs restriction enzymes and is proposed to belong to a subgroup of type II restriction enzymes called type IIf, which includes enzymes that cut downstream sequences at long distances.
Another significant patent by Jian-ping Xiao is a method for cloning and expression of NHEI restriction endonuclease in E. coli. This invention also relates to recombinant DNA that encodes the NheI restriction endonuclease and NheI methyltransferase. An internal NdeI site in the nheIR gene was eliminated by a silent mutation, and a new NdeI site was engineered at the start codon of the nheIR gene. The recombinant clone produces approximately 10 million units of NheI per gram of wet cells, showcasing the efficiency of this method.
Career Highlights
Jian-ping Xiao is currently associated with New England Biolabs, Inc., a leading company in the field of molecular biology. His work at this organization has allowed him to contribute to various innovative projects and advancements in biotechnology.
Collaborations
Throughout his career, Jian-ping Xiao has collaborated with notable colleagues, including Shuang-Yong Xu and Robert E Maunus. These collaborations have further enriched his research and development efforts.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.