Company Filing History:
Years Active: 1977-1990
Title: Innovations of Jesse L Bobbitt
Introduction
Jesse L Bobbitt is an accomplished inventor based in Indianapolis, IN (US). He has made significant contributions to the field of biochemistry, particularly in the area of protein purification and assay development. With a total of 2 patents, Bobbitt's work has advanced the understanding and application of recombinant proteins.
Latest Patents
One of Jesse L Bobbitt's latest patents is focused on the purification and refolding of recombinant proteins. This invention discloses a new method for solubilizing and refolding recombinant proteins expressed as granules. The method involves sulfitolysis and the formation of a precipitate of protein-S-sulfonate by warming. The precipitate has been found to contain protein in high purity. Additionally, proper folding occurs if the desired protein is fully reduced and passed through an intermediate concentration of denaturant, allowing for a transition between its folded and unfolded states. Another significant patent is related to a substrate for the assay of plasmin. This invention allows the proteinase plasmin to be assayed either colorimetrically or fluorometrically using a tripeptidyl-4-methoxy-2-naphthylamide substrate. This substrate is useful for both routine clinical assays and kinetic studies.
Career Highlights
Jesse L Bobbitt is currently employed at Eli Lilly and Company, where he continues to innovate and contribute to the field of biochemistry. His work has been instrumental in developing methods that enhance the efficiency and accuracy of protein assays.
Collaborations
Some of his notable coworkers include Joseph Vincent Manetta and Edward L Smithwick, Jr. Their collaborative efforts have further enriched the research environment at Eli Lilly and Company.
Conclusion
Jesse L Bobbitt's contributions to the field of biochemistry through his patents and work at Eli Lilly and Company highlight his innovative spirit and dedication to advancing scientific knowledge. His inventions are paving the way for future developments in protein research.