Jesper Wengel

Title: Jesper Wengel: Innovator in Nucleic Acid Derivatives

Introduction

Jesper Wengel is a prominent inventor based in Odense S, Denmark. He has made significant contributions to the field of nucleic acid chemistry, holding a total of 14 patents. His work focuses on innovative strategies for synthesizing Locked Nucleic Acid (LNA) derivatives and developing RNA complexes for therapeutic applications.

Latest Patents

One of Wengel's latest patents is titled "Synthesis of locked nucleic acid derivatives." This invention presents a novel strategy for synthesizing various LNA derivatives, including α-oxy-LNA, amino-LNA, α-amino-LNA, thio-LNA, α-thio-LNA, seleno-LNA, and methylene LNA. The method provides scalable, high-yield reactions utilizing intermediates that can also produce other LNA analogues, such as oxy-LNA. Another significant patent is "Small internally segmented interfering RNA," which focuses on pharmaceutical and therapeutic compositions comprising RNA complexes. These complexes include an antisense strand and a discontinued passenger strand capable of regulating gene expression. The use of a discontinued passenger strand reduces off-target effects and offers additional advantages.

Career Highlights

Throughout his career, Jesper Wengel has worked with notable companies, including Exiqon A/S and Santaris Pharma A/S. His expertise in nucleic acid chemistry has positioned him as a leader in the field, contributing to advancements in therapeutic applications.

Collaborations

Wengel has collaborated with esteemed colleagues, including Poul Sejer Nielsen and Troels Koch. These partnerships have further enhanced his research and development efforts in nucleic acid technologies.

Conclusion

Jesper Wengel's innovative work in the synthesis of nucleic acid derivatives and RNA complexes has made a significant impact in the field of biotechnology. His contributions continue to pave the way for advancements in gene regulation and therapeutic applications.