The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 23, 2013
Filed:
Dec. 23, 2011
Mads Detlef Sorensen, København, DK;
Jesper Wengel, Odense S, DK;
Troels Koch, København, DK;
Signe M. Christensen, København, DK;
Christoph Rosenbohm, Copenhagen, DK;
Daniel Sejer Pedersen, Cambridge, DK;
Mads Detlef Sorensen, København, DK;
Jesper Wengel, Odense S, DK;
Troels Koch, København, DK;
Signe M. Christensen, København, DK;
Christoph Rosenbohm, Copenhagen, DK;
Daniel Sejer Pedersen, Cambridge, DK;
Santaris Pharma A/S, Hoersholm, DK;
Abstract
The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as α--oxy-LNA, amino-LNA, α--amino-LNA, thio-LNA, α--thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising intermediates that also can produce other LNA analogues such as oxy-LNA. Also, the compounds of the formula X are important intermediates that may be reacted with varieties of nucleophiles leading to a wide variety of LNA analogues.