Company Filing History:
Years Active: 1989
**Title: Exploring the Innovations of Inventor Jens E. Larsen**
Introduction
Jens E. Larsen, a notable inventor based in Jordlose, Denmark, has made significant contributions to the field of biotechnology. With one patent to his name, he has focused on developing plasmids that exhibit conditional uncontrolled replication behavior, paving the way for advancements in cloning and gene expression.
Latest Patents
Larsen's patent, titled "Plasmids with conditional uncontrolled replication behavior," introduces innovative plasmids that serve as cloning vectors. These plasmids carry an inserted regulatable promoter, which controls the transcription and, consequently, the replication behavior of the plasmid. The increased transcription from the promoter allows for a substantially elevated or uncontrolled plasmid copy number when host microorganisms are cultivated under conducive conditions. The regulatable promoter is preferably the λP_R, which functions under the regulation of a temperature-sensitive λ cl repressor. Cultivating host microorganisms at about 30°C ensures a constant, low plasmid copy number during the initial stages, while shifting the temperature to 36°C-42°C facilitates an uncontrolled plasmid copy number, enabling amplified gene product yield.
Career Highlights
Jens E. Larsen works at A/S Alfred Benzon, a prominent company in the pharmaceutical and biotechnology sectors. His work focuses on the intersection of plasmid technology and microbial cultivation, furthering the potential for applications in genetic engineering and synthetic biology.
Collaborations
Throughout his career, Larsen has worked alongside talented individuals such as Soren Molin and Janice A. Light. Their collaborative efforts contribute to the innovative spirit present at A/S Alfred Benzon, fostering an environment where breakthroughs in biotechnology can thrive.
Conclusion
Jens E. Larsen's innovative approach to plasmid development holds great promise for advancements in cloning and gene product amplification. His contributions, in collaboration with esteemed colleagues, advance the field of biotechnology and showcase the impact inventors can have on scientific progress. With continually evolving technologies, the potential applications of such patents are vast, enhancing research capabilities in numerous domains.