Jehane Fadlallah

Title: Innovator Jehane Fadlallah: Pioneering Antibody Deficiency Treatment

Introduction

Jehane Fadlallah is an accomplished inventor based in Paris, France, known for her significant contributions to the field of immunology, particularly regarding antibody deficiencies. With two patents to her name, Fadlallah's work aims to enhance the understanding and treatment of conditions like Selective Immunoglobulin A Deficiency (SIgAd) and Common Variable Immunodeficiency (CVID).

Latest Patents

Her latest patent encompasses a novel composition for the treatment of antibody deficiencies. This groundbreaking invention demonstrates, for the first time, that systemic anti-microbiota IgG responses are correlated with reduced inflammation in both control subjects and IgA-deficient patients. Evidence suggests that systemic IgG responses play a critical role in confining gut microbiota, while inflammation associated with SIgAd is inversely correlated with systemic anti-commensal IgG responses, indicating a potential second line of defense. The findings suggest that both systemic IgG and intestinal IgA work together in different body compartments to limit systemic pro-inflammatory pathways. Furthermore, patients with selective IgA deficiency show elevated seric anti-commensal IgG levels, implying that microbiota confinement results in a stronger inflammatory response. The invention claims a composition containing immunoglobulins A (IgA), particularly secretory IgA, intended for oral administration to prevent or treat antibody deficiencies like SIgAd and CVID along with related inflammatory diseases.

Career Highlights

Fadlallah's career is marked by her tenure at prominent research institutions, including the National Institute for Health and Medical Research (Institut National de la Santé et de la Recherche Médicale) and Sorbonne Université. Her research has been pivotal in furthering the understanding of the immune system and improving therapeutic strategies for patients suffering from antibody deficiencies.

Collaborations

Throughout her career, Fadlallah has collaborated with esteemed colleagues, such as Guy Gorochov and Martin Larsen. These partnerships have facilitated groundbreaking research and innovations that have significantly impacted the field of immunology.

Conclusion

Jehane Fadlallah stands as a notable figure in the realm of immunology, with her patents serving as vital contributions to the treatment of antibody deficiencies. Her ongoing research and collaborations promise to further enhance understanding and methodologies in this crucial area of healthcare.