Jeffrey L Bessen is a notable inventor based in Somerville, MA (US). He has made significant contributions to the field of genetic engineering, holding a total of four patents. His work focuses on the evolution of site-specific recombinases and programmable fusion proteins, which have important implications for genome editing.

Latest Patents

One of his latest patents is titled "Evolution of site-specific recombinases." This patent provides methods for evolving recombinases to recognize target sequences that differ from canonical recognition sequences. It also includes evolved recombinases that bind and recombine naturally occurring target sequences, such as those within the human Rosa26 locus. Additionally, the patent outlines methods for using these recombinases for genetically engineering nucleic acid molecules both in vitro and in vivo. Another significant patent is "Programmable CAS9-recombinase fusion proteins and uses thereof." This patent describes a fusion protein that comprises a guide nucleotide sequence-programmable DNA binding protein domain, an optional linker, and a recombinase catalytic domain. This innovation represents a step toward programmable, scarless genome editing in unmodified cells.

Career Highlights

Jeffrey L Bessen is affiliated with Harvard College, where he continues to advance his research in genetic engineering. His work has garnered attention for its potential applications in various fields, including medicine and biotechnology.

Collaborations

Some of his notable coworkers include David R Liu and David B Thompson, who have collaborated with him on various projects related to his patents.

Conclusion

Jeffrey L Bessen's contributions to the field of genetic engineering through his innovative patents highlight his role as a leading inventor. His work continues to pave the way for advancements in genome editing technologies.

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